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Invention Publication
CN104955838A 双特异性EGFR/c-Met抗体 有权

双特异性EGFR/c-Met抗体
Abstract:
本发明涉及双特异性EGFR/c-Met抗体及制备和使用所述分子的方法。表皮生长因子受体(EGFR、ErbBI或HERI)是由c-erbBI原癌基因编码的170kDa I型跨膜糖蛋白。EGFR是受体酪氨酸激酶(RTK)的人表皮生长因子受体(HER)家族的成员，所述家族包括HER2(ErbB2)、HER3(ErbB3)和HER4(ErbB4)。EGFR信号传导通过如下方式引发：配体结合，之后诱导构象变化，所述受体与其他ErbB家族成员的同源二聚化或异源二聚化。
Abstract(English):

Bispecific EGFR/c-Met antibodies and methods making and using the molecules are provided. Epidermal growth factor receptor (EGFR, ErbBI or HERI) is a Type I transmembmne glycoprotein of 170 kDa thai is encoded by the c-erbBI proto-oncogene. EGFR is a member of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases (RTK) which includes HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4). EGFR signaling is initiated by ligand binding followed by induction of conformational change, homodimerizalion or heteromdimerization of the receptor with other ErbB family members.

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