The invention discloses an insecticide composition containing fluxapyroxad and fludioxonil. Effective constituents include the fluxapyroxad and the fludioxonil, the rest is an inert ingredient, the weight ratio of the fluxapyroxad to the fludioxonil ranges from 1:5 to 5:1, and the total weight of the fluxapyroxad and the fludioxonil accounts for 1%-90% of the weight of the composition; according to practical application requirements, the insecticide composition can be manufactured into one of an emulsion in water, a microemulsion, a suspending agent, wettable powder and a water dispersible granule, and is used for preventing and treating botrytis cinerea and a mango anthracnose disease. The insecticide composition is rapid in pesticide effect taking, long in lasting period, low in using cost and convenient to use, saves time and labor, and has the huge economic benefit and the huge social benefit on application and popularization.