The invention discloses a cryptotanshinone skin cutin liposomal preparation and a preparing method thereof. According to a formula, cryptotanshinone, lectin and cholesterol are dissolved in an organic phase, ceramide is dissolved in a water phase, preheating is allowed on a magnetic stirrer, the obtained organic phase is slowly dropped into the water phase, in which the ceramide is dissolved during magnetic stirring, and continuous stirring is performed to volatize the organic phase and transferred to a brown glass bottle for preservation. The cryptotanshinone skin cutin liposomal preparation has the advantages that the speed of the cryptotanshinone to permeate the skin can be evidently increased, and quantity of the preparation enters general circulation can be decreased at the premise of improving local effect; by preparation by means of organic solvent injection, the problems such that the cryptotanshinone is poor in water solubility and unstable are evidently improved, the speed of the cryptotanshinone to permeate through the cuticle can be increased, and a higher quantity of the preparation retains on the skin; the preparation can be prepared into various transdermal drugs, such as gels, ointments and plasters; the preparation is more widely applicable in the field of pharmaceuticals and cosmetics.