A capacitive touch substrate and a touch display screen are provided. The capacitive touch substrate comprises a plurality of groups of touch electrodes provided in parallel along a first direction. Each group of the touch electrodes includes: a plurality of first touch electrodes provided in a column along a second direction, which are driven independently; a second touch electrode extending along the second direction; and a third touch electrode extending along the second direction. The first touch electrode, the second touch electrode and the third touch electrode are provided sequentially along the second direction. The capacitive touch substrate improves touch accuracy on a premise that a number of wires is not changed and reduces the number of wires on a premise that the touch accuracy is not changed.