The invention discloses a pixel structure, a driving method, a display panel and a display device. Data lines are saved, high resolution of the display device is achieved under a condition of low power consumption and furthermore the display effects of the display device are raised. The pixel structure comprises a plurality of repeating groups. Each repeating group comprises three sub-pixels with different colors arranged in a line direction. The repeating groups in adjacent rows are staggered for one and half sub-pixels in a column direction. In the above pixel structure, three sub-pixels form two pixels, In a low physical resolution, the human eye spatial resolution characteristic can be utilized fully, and a high resolution is achieved through a mode that the sub-pixels are shared by a plurality of pixel units. if a sub-pixel with a color lacks a certain pixel position, the sub-pixels around the pixel position are lit to simulate the lacked color in the position. The pixel structure can save data lines compared with a pixel structure in the prior art.