The invention discloses a flickering reducing method for an electrophoretic display device during picture switching and the electrophoretic display device. The method comprises the following steps: receiving target gray scale information displayed by a pixel point; determining the driving waveform of a DC balance supplementary driving signal according to a new gray-scale flash driving signal of the pixel point under a previous state; driving the pixel point to a first extreme state from an original gray scale by virtue of a first extreme state driving signal; and driving the pixel point through a second extreme state driving signal so as to convert the pixel point from the first extreme state to a second extreme state, and applying the DC balance supplementary driving signal so as to keep the electrophoretic display device at DC balance and then converting pixel into a target gray scale by virtue of the new gray-scale flash driving signal. The second extreme state driving signal is identical to the DC balance supplementary driving signal in voltage direction. By optimizing the driving waveform and integrating the various stages of the driving waveform, the flickering reducing method disclosed by the invention can reduce the flickering times of the display screen of the electrophoretic display device, so as to improve the comfort level of electrophoretic electronic paper during picture switching.