The invention discloses a high-precision automatic-adjustment universal radial drill jig. The high-precision automatic-adjustment universal radial drill jig comprises a drill plate, a compression screw, a pressing plate and a nut. A cylindrical hole is formed in the middle of the drill plate. A plurality of grooves are formed in the wall of the cylindrical hole of the drill plate at intervals in the circumferential direction of the drill plate. A movable block capable of stretching out and retracting in the radial direction of the cylindrical hole is embedded in each groove. The side face, facing the cylindrical hole, of each movable block is a conical surface. Besides, the bottom of each movable block extends out of the lower end face of the drill plate and forms a spigot locating portion. The part, located below the pressing plate, of the screw is further sleeved with a guide sleeve assembly. The outer circle of the guide sleeve assembly is provided with conical surfaces and cylindrical surfaces alternately. The conical surfaces of the outer circle of the guide sleeve assembly are matched with the conical surfaces of the movable blocks in a one-to-one correspondence mode. The cylindrical surfaces of the outer circle of the guide sleeve assembly are matched with the wall of the cylindrical hole of the drill plate. According to the high-precision automatic-adjustment universal radial drill jig, the diameters of locating spigots can be automatically adjusted in a certain range, drill bushings with different inner diameters can also be replaced in a certain range, and the universality of the drill jig is greatly improved.