The invention provides a bipolar battery, a manufacturing method thereof and a vehicle comprising the bipolar battery. The bipolar battery comprises a case (1) comprising a first half case (2) and a second half case (3); at least one bipolar plate (4) with periphery sealed and clamped between the first half case (2) and the second half case (3); and at least two cores (5a, 5b) located at opposite two sides of the bipolar plate (4) respectively. With using the case (1) made of flexible packaging material and sealing the peripheries of the bipolar plate collector and the case (1) by sticking, it is easy to assemble and maintain the bipolar battery.