The invention provides Wuzhi Dixian Jinsui capsules and a preparation method thereof. The capsules are prepared from the following components in parts by weight: 50-100 parts of ginseng, 100-200 parts of bighead atractylodes, 150-300 parts of poria cocos, 100-200 parts of chrysanthemum, 100-200 parts of barbary wolfberry fruit, 200-400 parts of radices rehmanniae, 150-300 parts of radix ophiopogonis, 100-200 parts of pericarpium citri reticulatae, 100-200 parts of radix puerariae, 50-100 parts of fructus viticis and 150-300 parts of medicated leaven. The preparation method comprises the steps of: partially crushing radix puerariae into fine radix puerariae powder; extracting the residual radix puerariae to obtain radix puerariae filter residue and radix puerariae concentrate; decocting the radix puerariae filter residue with the rest of medical materials, mixing the decoction with the radix puerariae concentrate, concentrating, spray-drying, uniformly mixing with the fine radix puerariae powder, granulating, drying, totally mixing, filling, and subpackaging. The prepared Wuzhi Dixian Jinsui capsules are stable in quality, accurate in medicine content, convenient and rapid to take, and convenient for storage and transportation.