利索-全球专利检索

  1. 登录
  2. 注册
发明授权
CN105018541B (S)-叔丁基-2-羟基丙基氨基甲酸酯的合成方法 有权

(S)-叔丁基-2-羟基丙基氨基甲酸酯的合成方法
摘要：
本发明涉及一种(S)‑叔丁基‑2‑羟基丙基氨基甲酸酯的合成方法。主要解决现有合成方法成本高，反应复杂，且不适合规模化生产的技术问题。一种(S)‑叔丁基‑2‑羟基丙基氨基甲酸酯的合成方法，其特征是包括以下步骤：以1‑氨基‑2‑丙醇消旋体为原料，在二碳酸二叔丁酯存在下进行单BoC保护反应，并且进行氧化得到N‑BoC‑1‑氨基丙酮，再通过酶催化还原得到(S)‑叔丁基‑2‑羟基丙基氨基甲酸酯。纯度和手性纯度都在99%以上。该发明既适合进行大规模的工业化生产，又适合实验室的小批量制备。
摘要（英）：

The invention relates to a synthetic method of (S)-t-butyl-2-hydroxypropylcarbamate. The technical problems of high cost, complex reaction and unsuitableness for large scale production of present synthetic methods are mainly solved in the invention. The synthetic method of (S)-t-butyl-2-hydroxypropylcarbamate comprises the following steps: carrying out a single BoC protection reaction on 1-amino-2-propanol racemate as a raw material in the presence of di-tert-butyl dicarbonate, oxidizing to obtain N-BoC-1-aminoacetone, and carrying out enzymatic catalytic reduction to obtain (S)-t-butyl-2-hydroxypropylcarbamate. The purity and the chiral purity of (S)-t-butyl-2-hydroxypropylcarbamate are greater than 99% respectively. The method is suitable for large-scale industrial production, and is also suitable for laboratory small-scale preparation.

公开/授权文献
0/0