The invention discloses an intelligent manhole cover with a function of pressure power generation, and the manhole cover comprises a manhole cover body, an energy storage module, and a control module. The surface of the manhole cover body is provided with a plurality of pressure power generation modules in an embedded manner, and the pressure power generation modules are connected with the energy storage module. The pressure power generation modules enable unstable electric energy generated through pressure to be stored through the energy storage module after an external pressure is applied to the pressure power generation modules, so as to supply power to the control module. The manhole cover also comprises a communication module, a radio frequency module and a satellite positioning module, wherein the communication module, the radio frequency module and the satellite positioning module are respectively connected with the control module. After the radio frequency module is activated externally, the control module is activated, and enters into a working mode of intelligent interaction through the communication module or the radio frequency module. The control module is periodically dormant and started through triggering in a timing manner under the condition of no external activation intervention. The manhole cover achieves self-supply of power, intelligent interaction at a mode of low power consumption, theft prevention and alarm.