The invention relates to a completely-artificial hemibagrus wyckioides reproduction method. According to the method, individuals with remarkable growth rate advantages are selected from F1 progenies obtained through wild parent reproduction to serve as reserved parent fish, gender distinguishing is conducted after the reserved parent fish is over two years old, and then superior individuals are selected for cultivation and taken as artificial parent fish after being bred to over three years old; individuals from different wild parent combinations are selected from the artificial parent fish to serve as male and female parent fish for completely-artificial reproduction; odinagogue is injected into the female parent fish, and odinagogue is also injected into the male parent fish when odinagogue is injected into the female parent fish for the second time; dry artificial insemination is conducted by dissecting the male fish to take out testes and acquire seminal fluid and conducting egg stripping on the female fish, and then incubation and fry cultivation are conducted by routine. By the adoption of the method, the wild parents can be protected, cost for obtaining the wild parent fish can be reduced, labor force is saved remarkably, reproduction efficiency is improved, individuals with good growth traits can be selected in a targeted mode for reproduction, genetic diversity is maintained, and the problems of inbreeding and germplasm resource degradation during conventional reproduction are solved.