The invention provides food or a healthcare product or a medicine composition containing barbary wolfberry fruits and reducing blood glucose. The food or the healthcare product or the medicine composition comprises, by weight, 1-10 parts of barbary wolfberry fruits and 10-20 parts of malus hupehensis leaves. The barbary wolfberry fruits are obtained after fresh wolfberry fruits are punched through a puncher and dried. It is found that after the barbary wolfberry fruits and the malus hupehensis leaves are combined for use, the synergistic interaction effect is achieved, hypoglycemic activity is improved, and the effect is superior to that achieved through independent use of the barbary wolfberry fruits and the malus hupehensis leaves through research. It is further found that after the barbary wolfberry fruits and the malus hupehensis leaves are combined at the specific ratio of 5:15, the blood glucose reducing effect is better, and the effect is superior to that achieved through combination of barbary wolfberry fruits and malus hupehensis leaves at other ratios of 1:10 and 10:10 in experiments. Based on the research, the novel composition reducing blood glucose is provided for providing a new choice for clinical medication and healthcare treatment.