The invention discloses a radiation well drilling process, which comprises construction of a vertical shaft and drilling of radial holes, wherein a guide drilling mast is vertically arranged, and is connected with a rotary drilling machine bit to downwardly rotatably dig and drill, a digging bucket is upwardly lifted after being filled, rotary drilling objects in the digging bucket are poured out, the vertical shaft is hoisted to put into a cement cylinder, and sandy gravels are put into the bottom portion of the vertical shaft. The guide drilling mast is connected with a drilling rod and a detection bit, a guide drilling machine drills, and the detection bit passes through the vertical shaft to continue drilling until the detection bit reaches a target to basset. The detection bit is dismounted, the drilling rod is connected with a screen pipe, the screen pipe is pulled back until being exposed from an original penetrating position, and the screen pipe is sheared. The radiation well drilling process molds a big diameter vertical shaft at one time by utilizing rotary drilling technology, a penetrated cement cylinder skeleton is a bamboo strip skeleton, and the vertical shaft cement cylinder is penetrated by adopting the guide drilling mast. Two radial holes are formed at one time during the construction process, and are pulled back to form by adopting flexible plastic pipes. The radiation well drilling process saves time and labor, does not need workers to descend a well, and is high in safety.