Techniques disclosed herein include systems and methods for a bone screw and self-retaining driver. The system includes a mechanism that enables a bone screw to be rigidly attached to a screwdriver for manipulation and transfer of bone fragments and grafts to a fixation site, such as during surgery. The system includes a cannulated bone screw that has a drive connection that engages with a drive structures of a screwdriver. The bone screw also includes a structural connector that securely attaches to or receives an internal shaft or rod of the screwdriver. The internal shaft or rod of the screwdriver can rotate and slide independent of an outer shaft of screwdriver. Accordingly, the internal shaft of the screwdriver can rigidly connect with the bone screw enabling applied torque to the screwdriver to be transferred to the bone screw, without the bone screw falling off of the drive connection.