Provided is a cleaning device for substation secondary equipment. A rotary worktable is arranged in a sealed chamber. Main air blowers are distributed at the corners of the left side and the right side of the sealed chamber. Auxiliary air blowers are distributed on a worktable support. A dust collector is arranged on the top of the sealed chamber. Dust sensors are arranged on the left inner wall and the right inner wall of the sealed chamber, and the dust sensors are connected with a signal processing system. A sliding way is arranged on the front side of the sealed chamber and provided with a connection sliding seat. An operating rod is connected with a rotation shaft through the connection sliding seat. A camera is arranged at the upper end of the inner surface of the front wall of the sealed chamber. A display screen is arranged on the top of the sealed chamber. The operating rod is sleeved with a strip-shaped rubber sealing cover which covers a straight groove opening in the front wall of the sealed chamber. According to the cleaning device for the substation secondary equipment, cleaning is complete, the phenomenon that dust falls backwards is avoided, and excessive restriction of the weather factor on cleaning work is eliminated; in the cleaning process, removed dust is collected and can not diffuse outwards to affect the surrounding environment, and harm to body health of cleaners is avoided.