The invention discloses a portable insulating barrier suitcase for a high-voltage switch cabinet. The portable insulating barrier suitcase comprises a case body and a case cover, wherein the case cover is articulated with the case body and is matched with the case body; vertical fixed blocks are arranged in the case cover; a sliding rail is arranged on the fixed block; a first isolated insulating barrier capable of sliding along the sliding rail is arranged on the sliding rail; the height of the fixed block is greater than the depth of an inner cavity of the case cover; the first isolated insulating barrier can slide out of the case cover along the sliding rail; and in a normal state, the first isolated insulating barrier is arranged in the case cover. According to the portable insulating barrier suitcase, the problems that an existing barrier or barrier trolley is poor in reliability and low in universality can be effectively solved; the risk of injuries and deaths of operating personnel caused by electric shock is effectively avoided; the portable insulating barrier suitcase is simple in structure, simple and convenient to operate and convenient to carry, and can be widely applied to the field of the insulating barrier of the high-voltage switch cabinet; and the work efficiency can be effectively improved.