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发明公开
CN105073141A 用于将基因递送到细胞的功能化DNA树状聚合物 无效 - 撤回

用于将基因递送到细胞的功能化DNA树状聚合物
摘要：
本发明公开了包含连接有一个或多个DNA序列的DNA树状聚合物的组合物，所述DNA序列包含编码多肽或调控RNA的DNA序列，所述DNA序列与调控所述编码多肽或调控RNA的DNA序列的表达以产生编码所述多肽的RNA或产生所述调控RNA的DNA序列连接。还公开了通过将所述树状聚合物递送到细胞，随后表达所编码的多肽或调控RNA来治疗细胞的疾病和病症的方法。
摘要（英）：

Compositions are disclosed which comprise a DNA dendrimer having one or more DNA sequences linked thereto, the DNA sequences comprising DNA sequences encoding a polypeptide or regulatory RNA linked to DNA sequences that regulate expression of the DNA sequences encoding a polypeptide or regulatory RNA to produce an RNA coding for the polypeptide or to produce the regulatory RNA. Also disclosed are methods for treating diseases and conditions of cells by delivering the dendrimers to the cells, with subsequent expression of the encoded polypeptide or regulatory RNA.

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