The invention provides a vertical cold isostatic press. The vertical cold isostatic press is characterized by comprising a high-pressure container and a seal end cover, wherein the high-pressure container is vertically arranged, and the top of the high-pressure container is open; the seal end cover is fixedly matched with the open end of the high-pressure container in a threaded manner, and the seal end cover comprises a threaded fixing seat and a seal seat which are arranged in a vertically split manner; the threaded fixing seat is fixedly matched with the high-pressure container in a threaded manner, and the seal seat is matched with the high-pressure container in a sealed manner; the threaded fixing seat can rotate independently relative to the seal seat, and an elastic mechanism is arranged between the threaded fixing seat and the seal seat; the elastic mechanism enables a certain separation gap to be formed between the threaded fixing seat and the seal seat, and the seal seat is connected to a connecting shaft penetrating through the center of the threaded fixing seat; and the connecting shaft is connected to a suspension mechanism enabling the seal end cover to be in a balance force state. By the adoption of the vertical cold isostatic press, on the basis of a horizontal type cold isostatic press, the situation that wear of a seal ring on the seal end cover is accelerated due to rotation is avoided, and meanwhile the vertical cold isostatic press is high in working stability, low in operation load, capable of being rapidly started and convenient to use.