The invention discloses a purification method of chromatographic-grade tetrahydrofuran. The purification method is characterized in that impurities in a raw material tetrahydrofuran are removed through processes such as modified activated carbon adsorption and the like so as to obtain chromatographic-grade tetrahydrofuran. By the purification method of chromatographic-grade tetrahydrofuran, tetrahydrofuran with its purity being greater than or equal to 99.99 wt% can be obtained, thus meeting high-purity requirement of a chromatographic-grade reagent. The tetrahydrofuran obtained after purification can be applied in fields of chromatographic analysis, chromatographic separation, chromatographic preparation and the like, and application range of the tetrahydrofuran is broadened.