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发明公开
CN105085641A 一种细胞膜定位信号肽及其编码序列和应用 有权

一种细胞膜定位信号肽及其编码序列和应用
摘要：
本发明涉及基因工程技术领域，具体地涉及一种细胞膜定位信号肽及其编码序列和应用。信号肽为(a)或(b)；(a)由序列表中序列2所示的氨基酸序列组成的多肽；(b)将序列2的氨基酸序列经过一个或几个氨基酸残基的取代和/或缺失和/或添加且具有细胞膜定位信号肽功能的衍生多肽。本发明提供的信号肽可以将目标蛋白靶向定位于宿主细胞膜上。本发明提供的细胞膜定位信号肽与合适的目标蛋白形成融合蛋白，可用于开发治疗病毒、寄生虫、细菌感染的疫苗和药物，并实现高效给药。
摘要（英）：

The invention relates to the field of genetic engineering technologies, in particular to cytomembrane positioning signal peptide and coding sequence and application thereof. According to the cytomembrane positioning signal peptide and coding sequence and application, (a) or (b) serves as the signal peptide; (a) is polypeptide composed of an amino acid sequence as shown in a sequence 2 in a sequence table; (b) is derivative polypeptide with a cytomembrane positioning signal peptide function and formed by conducting replacing and/or deletion and/or adding of one or more amino acid residues on the amino acid sequence of the sequence 2. The signal peptide can locate target protein to the host cytomembrane. The cytomembrane positioning signal peptide and proper target protein form infused protein to be used for developing vaccine and medicine for treating virus, parasites and bacterial infection and achieve efficient dosing.

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