The invention relates to the technical field of railway vehicle brake maintenance technology calibration devices, and especially relates to a 120-type valve and empty and load test bench pressure sensor sampling channel calibration device. A device capable of accurately calibrating a 120-type valve and empty and load test bench pressure sensor sampling channel is provided, comprising a bottom plate, a threaded joint, a joint nut, a threaded joint plug, a pressure gauge, a filter, and a threaded joint nut. The bottom plate includes a fixed base and a vertical plate, and the vertical plate is perpendicularly connected with the fixed base. The threaded joint passes through a circular hole in the vertical plate to be fixed to the bottom plate. The threaded joint is provided with a step at one side and an external thread at the other side, and the step can completely fit the vertical plate of the bottom plate. The threaded joint nut and the external thread match each other to fasten the threaded joint. The inner side of the step of the threaded joint is provided with an internal thread. The thread of the filter and the internal thread are fixed inside the threaded joint in a matching manner. The 120-type valve and empty and load test bench pressure sensor sampling channel calibration device of the invention is mainly applied to railway vehicle brake maintenance.