The present invention relates to a process for the treatment of a leather, imitation leather or fabric semimanufactured product. The process comprises the steps of: - providing the semimanufactured product to be treated; - preparing a treatment solution comprising a binder solution and particles comprising silver ions in the form of insoluble or slightly soluble salts; - applying said treatment solution to at least one surface of said semimanufactured product to be treated, Said binder solution comprises natural proteins in aqueous solution. The present invention also relates to an item produced from a leather, imitation leather or fabric semimanufactured product treated with the aforesaid.