The invention provides a sanitary towel with a concave-convex surface layer. The sanitary towel is characterized by comprising a skin-friendly surface layer, a flow guide layer, an absorption core layer and an anti-leaking bottom layer which are sequentially arranged from top to bottom, wherein a concave-convex line structure is formed on the skin-friendly surface layer; liquid is rapidly dispersed along a concave part through the stereoscopic concave-convex line structure and infiltrates rapidly; the contact area with human body skin can be reduced by concave-convex lines so that the sanitary towel is more ventilated, dry and comfortable.