The invention relates to microsphere capsules with an assistant protection function on gastric mucosal lesion. The microsphere capsules are prepared from, by weight, 20-40 parts of chitosan, 25-55 parts of pilose asiabell root extract, 20-50 parts of langehead atractylodes rhizome extract and 8-12 parts of radix notoginseng extract. The microsphere capsules with the assistant protection function on the gastric mucosal lesion have the advantages that the chitosan is taken as a carrier to be combined with the traditional Chinese medicines, and the chitosan and pilose asiabell root extract, langehead atractylodes rhizome extract and radix notoginseng extrac mutually cooperate for compatibility to achieve the effect of protecting the gastric mucosa; meanwhile, microspheres with the particle size about 10-150 micrometers are prepared by adopting an ultrasonic emulsion technology, absorption is good, and the bioavailability is high.