The invention discloses an anti-blockage fertilizer screening device which comprises a rack, a motor, a cover and a cylindrical screen. The cover is fixed to the rack. The cylindrical screen is obliquely arranged in the cover and driven by the motor. The anti-blockage fertilizer screening device further comprises multiple collision structures arranged in the axial direction of the cylindrical screen. The collision structures comprise guide seats, collision blocks, elastic pieces and press blocks. The guide seats are installed in the cover. The collision blocks are connected into the guide seats in a sliding mode. The elastic pieces are located between the collision blocks and the guide seats. The multiple press blocks are arranged on the outer wall of the cylindrical screen and arranged corresponding to the multiple collision structures. Each press block can intermittently extrude the corresponding collision block. By the adoption of the scheme, in the screening process, the screen cannot be blocked.