The invention relates to a recombinant common omega-interferon and an application thereof, and belongs to the field of molecular biology. The amino acid sequence of the recombinant common omega-interferon (CoBoIFN-omega) is represented by SEQ ID No.1, and a nucleotide sequence for encoding CoBoIFN-omega is represented by SEQ ID No.2. The CoBoIFN-omega realizes efficient and soluble secretion and expression in Pichia pastoris, and an antiviral activity experiment result confirms that the CoBoIFN-omega has strong VSV pathology formation inhibition ability in MDBK and PK-15 cells, the VSV pathology formation inhibition ability of the CoBoIFN-omega in the MDBK is 3.93 times higher than that of BoIFN-omega 24 in the MDBK cell, and the VSV pathology formation inhibition ability of the CoBoIFN-omega in the PK-15 cell is 12.8 times higher than that of the BoIFN-omega 24 in the PK-15 cell. The antiviral activity of the CoBoIFN-omega is greatly higher than that of other similar products, so the CoBoIFN-omega is more suitable for clinic application and industrial exploitation.