The invention discloses a polytetrafluoroethylene bonded solid lubricant. The polytetrafluoroethylene bonded solid lubricant is prepared with polyamide-imide resin and epoxy resin as binders, polytetrafluoroethylene, melamine cyanurate and molybdenum disulfide as solid lubricants and a mixed solvent as a diluent, and contains various fillers and a modification additive. The lubricant is coated on the surfaces of mechanical components and test samples, and is heated and solidified to form polytetrafluoroethylene bonded solid lubrication coating layers. The lubricant solves the problems of lubrication and wearing of motion parts under low load and high speed conditions, such as wearing and lubrication problems between oil-free compressor rotors and between rotors and a shell, and is especially suitable for being used on screw type oil-free air compressors.