The invention discloses a high temperature high pressure horizontal well completion pipe string with a middle shut-in well injected with a hypobarism liquid; the high temperature high pressure horizontal well completion pipe string comprises a shaft and a naked eye horizontal segment arranged below the shaft, and also comprises an upper completion pipe string, a middle temporary shut-in well pipe string, and a punching pipe suspension pipe string; a tail tube hang suspension packer on the top of the punching pipe suspension pipe string interpenetrates and is fixed in a lower port of the shaft, and the bottom of the punching pipe suspension pipe string is sued for fixing and connecting with a horizontal pipe string in the naked eye horizontal segment; the bottom of the middle temporary shut-in well pipe string interpenetrates an upper port of the punching pipe suspension pipe string, and the top of the middle temporary shut-in well pipe string is packed and fixed in the shaft; the top of the upper completion pipe string suspends in the upper port of the shaft, the bottom of the completion pipe string penetrates the suspension packer and interpenetrates in an upper port of the middle temporary shut-in well pipe string, and the hypobarism completion pipe liquid is arranged above the suspension packer in the shaft. The high temperature high pressure horizontal well completion pipe string can realize annular sleeve corrosion protection, can directly pressurize to open a production channel after a production pipe string is placed, thus realizing liquid drainage production.