The invention relates to a simulation experiment device and method for slippage between reservoir pressure change inducing layers. According to the simulation experiment device for slippage between the reservoir pressure change inducing layers, the two side walls of a rack are each provided with hydraulic rods, an upper pressing assembly and a lower pressing assembly are connected with the hydraulic rods on the two sides respectively, and pressure heads of the upper pressing assembly and pressure heads of the lower pressing assembly are correspondingly arranged. The upper pressing assembly and the lower pressing assembly are both composed of a plurality of pressure devices mounted side by side. Each pressure device comprises a first support, an oil cylinder, a second support and one corresponding pressure head. Guide rods are mounted at the two ends of each first support, each pressure head is fixed to the lower ends of the corresponding guide rods, and each oil cylinder is mounted on the corresponding first support and located between the two corresponding guide rods. The upper ends of the second supports are connected with piston rods of the oil cylinders, and the lower ends of the second supports are connected with the pressure heads. Pressure sensors are mounted at the two ends of each second support. According to the simulation experiment device and method, the law of casing damage caused by stratum slippage in marker beds of Daqing Oilfield can be studied.