The present invention discloses a blood glucose meter product calibration circuit, which comprises a calculation amplifier, a feedback resistor, a first calibration resistor and a second calibration resistor, wherein the inverted input terminal of the calculation amplifier is subjected to zero load to obtain a first measurement result, the inverted input terminal of the calculation amplifier is connected with the first calibration resistor to obtain a second measurement result, the inverted input terminal of the calculation amplifier is connected with the second calibration resistor to obtain a third measurement result, and according to the first measurement result, the second measurement result and the third measurement result, the true value of the reference voltage is obtained. According to the present invention, in the calibration circuit, the precisions of the first calibration resistor and the second calibration resistor are one-grade higher than the feedback resistor, and the error of the adjustable resistor during the adjusting process can be counteracted through the multiple measurements, such that the measurement precision of the reference voltage of the blood glucose meter product is improved.