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发明公开
CN105143162A 合成方法 有权 转让

合成方法
摘要：
描述了通过使3-(5-乙氧基庚-1-基)环戊烯与二氯乙烯酮反应来合成6-(5-乙氧基庚-1-基)双环[3.3.0]辛烷-3-酮的方法。使所得反应产物与乙酸和锌反应以产生4-(5-乙氧基庚-1-基)双环[3.2.0]庚烷-6-酮和4-(5-乙氧基庚-1-基)双环[3.2.0]庚烷-7-酮，使其与三甲基碘化锍反应以产生2-(5-乙氧基庚-1-基)螺[双环[3.2.0]庚烷-6，2’-环氧乙烷]和4-(5-乙氧基庚-1-基)-螺-[双环-[3.2.0]庚烷-6，2’-环氧乙烷]。使碘化锂与2-(5-乙氧基庚-1-基)螺[双环[3.2.0]庚烷-6，2’-环氧乙烷]和4-(5-乙氧基庚-1-基)螺-[双环-[3.2.0]庚烷-6，2’-环氧乙烷]反应以产生6-(5-乙氧基庚-1-基)双环[3.3.0]辛烷-3-酮。还描述了合成6-(5-甲氧基庚-1-基)双环[3.3.0]辛烷-3-酮的方法。
摘要（英）：

Described is a method of synthesizing 6-(5-ethoxyhept-1-yl)bicyclo[3.3.0] octan-3-one by reacting 3-(5-ethoxyhept-1-yl) cyclopentene with dichloroketene. The resulting reaction products are reacted with acetic acid and zinc to produce 4-(5-ethoxyhept-1 -yl)bicyclo[3.2.0]heptan-6-one and 4-(5-ethoxyhept-1-yl)bicyclo [3.2.0]heptan-7-one, which are reacted with trimethylsulfonium iodide to produce 2-(5-ethoxyhept-1-yl)spiro[bicyclo[3.2.0]heptane-6,2'-oxirane] and 4-(5-ethoxyhept-1-yl)spiro-[bicyclo-[3.2.0]heptane-6,2'-oxirane]. Lithium iodide is reacted with 2-(5-ethoxyhept-1-yl)spiro[bicyclo[3.2.0]heptane-6,2'-oxirane] and 4-(5-ethoxyhept-1-yl)spiro-[bicyclo-[3.2.0]heptane-6,2'-oxirane] to produce 6-(5-ethoxyhept-1-yl)bicyclo[3.3.0]octan-3-one. A method of synthesizing 6-(5-methoxyhept-1-yl)bicyclo[3.3.0]octan-3-one is also described.

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