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发明公开
CN105148283A 一种创新药用辅料蔗糖丸芯及其制备方法 无效 - 驳回

一种创新药用辅料蔗糖丸芯及其制备方法
摘要：
一种药用辅料蔗糖丸芯及其制备方法，包含78％～98％蔗糖，0.5％～9％糊精，1％～14％淀粉，将1/3处方量的蔗糖、1/3处方量的糊精、1/3处方量的淀粉为原料，以水为粘合剂起母为核，采用1/3处方量的蔗糖、1/3处方量的淀粉，1/3处方量的蔗糖、1/3处方量的糊精，1/3处方量的淀粉、1/3处方量的糊精作为第一层、第二层及第三层放大，通过控制放大层物料有效保证微丸脆碎度、圆整度及引湿性。制得的微丸圆整度高，脆碎度低，引湿性低。
摘要（英）：

The invention provides an innovative pharmaceutic adjuvant sucrose pill core and a preparation method thereof. The innovative pharmaceutic adjuvant sucrose pill core is prepared from 78-98% of sucrose, 0.5-9% of dextrin and 1-14% of starch. One third of sucrose in the formula, one third of dextrin in the formula and one third of starch in the formula serve as raw materials and are mixed with water as a bonding agent to form a core. One third of sucrose in the formula and one third of starch in the formula serve as a first layer, another one third of sucrose in the formula and one third of dextrin in the formula serve as a third layer, another one third of starch in the formula and another one third of dextrin in the formula serve as a third layer, and the first layer, the second layer and the third layer are amplified. By controlling materials of the amplified layers, the friability, rounding degree and hygroscopicity of a pellet are effectively ensured. The prepared pellet is high in rounding degree, low in friability and low in hygroscopicity.

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