The invention relates to an early pelvic organ prolapse diagnosis and treatment marker and application thereof, in particular to application of a ZCCHC12 gene and/or KCNG1 gene to early pelvic organ prolapse diagnosis and treatment. The inventor performs gene screening through analysis by adopting a biological information method based on high-throughput sequencing results, selects out candidate genes ZCCHC12 gene and KCNG1 gene and further proves a relation between the candidate genes and the pelvic organ prolapse through a molecular cell biological method; the candidate genes have a very good correlation with the pelvic organ prolapse, the candidate genes are found to be obviously highly expressed at the early stage of the pelvic organ prolapse in combination with clinical staging, the marker can be used for preparing an auxiliary diagnosis and treatment preparation for early pelvic organ prolapse, and the clinical application value is important.