The invention discloses a configuration method for sectionalizing and interconnection switches of a power distribution network. The method comprises the following steps: collecting parameters required for current situation data of the power distribution network and model building, and building a standardized power distribution network power supply model; setting different power supply region reliability targets, namely comparing different load densities and power supply radiuses and setting the target according to the requirements, which are stipulated by a guide rule, of the power supply region grades on the reliability, so as to achieve the power supply reliability of making customers satisfied; evaluating a connection mode; and recommending schemes for regions with different load levels. The configuration method has the beneficial effects that the entire life-cycle cost of the connection mode is considered aiming at the reliability requirements of different grades of power supply regions; the sectionalizing and interconnection switches are reasonably configured; the optimal connection mode is selected; the reasonability of the power distribution network is comprehensively improved; a good reference is provided for power distribution network planners for power distribution network planning and construction; a strong technical support is provided for power distribution network planning work in the future; and the method is easy to grasp and operate.