利索-全球专利检索

  1. 登录
  2. 注册
发明授权
CN105164162B 用二羧酸酯化的纤维素醚 失效 - 权利终止

用二羧酸酯化的纤维素醚
摘要：
酯化纤维素醚，其适用作将不良水溶性药物于水性液体中的浓度维持在过饱和水平下的赋形剂，所述酯化纤维素醚包含下式的基团：‑C(O)‑CHR′‑CHR″‑COOA，其中R′和R″是氢或(‑S)m(‑R1)n‑R2，其中R1是具有1到4个碳原子的烃基，R2是任选地经取代的5或6元环基，m和n各自独立地是0或1，并且A是氢或阳离子，其条件是在每个基团CHR′‑CHR″中，R′和R″中的一者是氢并且另一者是(‑S)m(‑R1)n‑R2。
摘要（英）：

Esterified cellulose ethers comprising groups of formula —C(O)—CHR′—CHR″—COOA, wherein, R′ and R″ are hydrogen or (—S)m(—R1)n-R2, wherein R1 is a hydrocarbon group having 1 to 4 carbon atoms, R2 is an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation, with the proviso that in each group CHR′—CHR″ one of R′ and R″ is hydrogen and the other one is (—S)m(—R1)n-R2, are useful as excipients for maintaining the concentration of poorly water-soluble drugs in aqueous liquids at supersaturation levels.

公开/授权文献
0/0