The invention discloses a vehicle safety protection control device and a vehicle safety protection control method. The device comprises a monitoring module and a control module, wherein the monitoring module is used for monitoring an inclination direction and an angle, relative to a road surface, of a vehicle; and the control module is used for calculating a danger coefficient of each taken seat in the vehicle according to the inclination direction and the angle, relative to the road surface, of the vehicle, and controlling a safety protection device for the taken seat with the danger coefficient higher than a danger threshold value to operate. According to the technical scheme provided by the invention, when the vehicle is inclined, the safety protection device for the taken seat with the danger coefficient higher than the danger threshold value is controlled to operate, so that the safety of people in the vehicle is guaranteed.