The invention provides a method, a device and a system for evaluating the risk of a power grid operation mode with the equipment health state. According to the method, the device and the system, topological data in maintenance is generated by utilizing current power grid topological data, current power grid operation data and imported equipment and outage time thereof in a maintenance plan, the topological data of the power grid is substituted into a 'risk evaluation analysis model with the equipment health state' for analyzing, and the risk of the power grid operation mode is evaluated, so that real-time power grid risk evaluation including maintenance time span is realized; and a failure which does not occur is predicted and quantitatively evaluated, so that power grid operation and management staff can reasonably arrange a maintenance timing sequence and adopt an effective measure in time to reduce voltage loss of the power grid, and reliability power supply for users and safety of power equipment operation can be guaranteed.