The invention provides a mine water inrush real-time monitoring, early warning and escape guide system and belongs to the mine early warning technical field. The system includes a mine water inrush monitoring and early warning device and a mine water inrush simulation system; the mine water inrush monitoring and early warning device includes host machines, slave machines a switch and a server; the mine water inrush simulation system is hosted by the server; after the server establishes a mine three-dimensional model and positions the position of the slave machines, the slave machines transmits mine information with appointed time intervals through a wireless ad hoc network, wherein the mine information is monitored in real time by sensor modules of the slave machines; the host machine integrates slave machine information and transmits the information to the server, so that water inrush simulation can be carried out; and after being dynamically corrected, simulation results are respectively transmitted to managers and underground personnel in the forms of dynamic simulation display and switching on guide lights. Related data of the system can be used for later-stage analysis and research. With the mine water inrush real-time monitoring, early warning and escape guide system adopted, a whole process before and after water inrush can be dynamically displayed in a simulated manner, and personnel positioning can be realized, and mine water inrush rescue can be effectively assisted.