The invention relates to a regional power grid real-time scheduling plan adjustment method. The method comprises the following steps: acquiring peripheral data; acquiring a planned output of a unit of each province from an uploaded data file of a provincial dispatching unit; in consideration of a super short period load of each province, acquiring a real-time generation scheduling deviation; acquiring an assessment index according to the plan execution condition of each province; calculating a deviation automatic distribution coefficient of each province according to the assessment index; respectively calculating a network dispatching deviation and a provincial dispatching deviation of each province, and equally distributing the network dispatching deviation to each unit. The regional power grid real-time scheduling plan adjustment method provided by the invention effectively achieves an application of provincial power grid information in the real-time scheduling plan work, and enhances the flexibility and controllability of the real-time scheduling plan.