A mobile wireless device/platform dynamically selects or instantiates a desired interface to improve conditions related to the mobile (multi-radio) wireless device, such as power consumption savings, radio coexistence mitigation, electromagnetic interference (EMI) reduction, etc. In one instance, the mobile wireless device identifies one or more hardware interfaces in a mobile wireless device host. The mobile wireless device then dynamically selects the one or more hardware interfaces to facilitate communication between a peripheral device and the mobile wireless device host.