The invention discloses a maca wine and a preparation method thereof. The maca wine is prepared from the following raw materials in part by weight: 900-1000 parts of base liquor, 10-30 parts of maca, 1-2 parts of cultivated ginseng, 6-8 parts of the fruit of Chinese wolfberry, 1-5 parts of longan, 2-10 parts of jujubes, 2-8 parts of raspberry, 1-5 parts of sealwort extracts, 1-5 parts of extracts from pueraria and 0.5-3 parts of cordyceps militaris extracts. The preparation method comprises the following steps of pretreatment, extraction, mixing and after-treatment. The maca wine does not have traditional drug flavor, tastes good, and has effects of nourishing yin, reinforcing qi, refreshing and boosting immunity; and after drinking the maca wine, a person does not have a headache.