The invention provides an LED drive circuit capable of achieving current matching. The LED drive circuit comprises a reference current source, a first resistor and multiple LED drive branch circuits; the first connecting end of the first resistor is connected with the output end of the reference current source, and the second connecting end of the first resistor is connected with the grounded end; each LED drive branch circuit comprises a programmable operational amplifier, an output transistor, a drive resistor and an offset calibration circuit, wherein the first connecting end of the output transistor serves as the output end of the LED drive branch circuit and can be connected with a driven LED, the first input end of the offset calibration circuit is connected with the first connecting end of the first resistor, the second input end of the offset calibration circuit is connected with the second input end of the programmable operational amplifier, and the first resistor are mutually matched with matching resistors to reduce relative errors between the first resistor and the matching resistor. By means of the characteristic that the relative errors of the matching resistors are small, more consistent LED drive currents can be supplied.