The invention relates to the technical field of agriculture, in particular to an ecological method for preventing and controlling a mulberry sorosis sclerotium disease. Acid oxidation-reduction potential water is adopted to spray the ground, tree bodies and air in a mulberry field, and the method particularly comprises the following steps that the water is sprayed for one time every 3-4 days from late February to early March, sprayed for one time every 5-6 days from middle March to middle April and sprayed for one time every 7-8 days from late April to early May. According to the method, ascospores formed through germination of mulberry sorosis sclerotia in apothecia can be killed, and the purpose of preventing and controlling the mulberry sorosis sclerotium disease is achieved; the killing effect of the method is more significant than that of insecticides such as carbendazim, thiophanate methyl and 95% glyphosate wettable powder; compared with a traditional pesticide preventing and controlling method, the preventing and controlling method has the advantages that pesticide pollution and residues of mulberry soroses are avoided, the sclerotium ascospores can be quickly and efficiently killed, the cost is low, no phytotoxicity is generated to the tree bodies, no harm is generated to the human body, and operation is convenient.