The invention belongs to the field of food processing, and particularly relates to a manufacturing method of toxin expelling plum. The method comprises eight steps of raw material selection, sorting and screening, raw material processing, heating, sugaring solution preparation, sugaring, draining and packaging. A low-temperature pickling method is used, so that the effective ingredient loss of plum flesh extraction liquid, organic acid and the like is little; in addition, desalination is not needed during the processing; fragrance such as benzaldehyde and phenylcarbinol in fruits is still partially remained; meanwhile, in the sugaring process, liquorice and xylooligosaccharide are used for replacing partial white granulated sugar; a vacuum gel infusion and sugar infusion process is used in a matched way, so that the time can be saved; the eating mouthfeel of the plum is enhanced; the refreshing fragrance is realized; the effects of expelling toxin, facilitating feces excretion, reducing weight and building the body can also be achieved.