The invention relates to an anti-misoperation lock of a ground lead. The anti-misoperation lock comprises a lock body and a lock pin. The lock body comprises a shell. An unlocking mounting cavity, a locking mounting cavity, a code reorganization mounting cavity and lock holes allowing the lock pin to be inserted are arranged in the shell. A first unlocking inserting hole matched with a computer key transmission locating pin, a second unlocking inserting hole matched with a five-prevention computer key unlocking rod and a code recognizer matched with a five-prevention computer key wireless probe are arranged in the code reorganization mounting cavity. A locking assembly is arranged in the unlocking mounting cavity, and an unlocking pin head extending into the first unlocking inserting hole along the end of the locking assembly is arranged at one end of the locking assembly. A stop pin is vertically arranged in the second unlocking inserting hole. A sliding assembly used for driving the stop pin to be in an unlocking or locking state is arranged in the locking mounting cavity. The number of the lock holes is four. The operation safety of the ground lead is improved, and the situation that operators forget to arrange the ground lead in the operation process, and consequently accidents are caused is avoided.