An intelligent line loss detection device disclosed by the present invention comprises a data acquisition metering module, a GPRS module and a monitoring center, the data acquisition metering module acquires the data via a line loss detector, transmits the data to the GPRS module and sends to the monitoring center, and the line loss detector comprises a C8051F020 single-chip microcomputer, a metering chip, a power supply module, a voltage sensor and a closed-loop current sensor. The voltage sensor and the closed-loop current sensor are connected with a voltage transformer and a current transformer respectively, and the GPRS module is connected with the C8051F020 single-chip microcomputer. The intelligent line loss detection device of the present invention can detect the line loss information effectively, acquires the data automatically and analyzes, is accurate to measure, is high in efficiency, can emit to the monitoring center via the GPRS module, can know the line loss problem timely, and can remedy timely according to the serious situations.