The present invention discloses a GPRS amplifier and a wireless meter reading system. The GPRS amplifier comprises a first shielding box provided with a duplexer and used for receiving signals and amplifying and sending out the received signals; a second shielding box connected with the duplexer and used for transmitting signals transmitted to the duplexer by a GPRS electric meter; and a third shielding box connected with the duplexer and used for transmitting the signals amplified by the duplexer to a remote receiving end, wherein the second shielding box and the third shielding box are arranged at two sides of the first shielding box. The problem that signal interferences are easy to occur in GPRS signal transmission in the prior art is solved, and the effect of reducing signal interferences in GPRS signal transmission is thus achieved.