The invention relates to an automatic ultrasound cleaning machine based on image processing and an operating method thereof. The automatic ultrasound cleaning machine comprises an image acquiring unit for acquiring fruit and vegetable image data; a weighing sensing unit for obtaining weight data of fruits and vegetables placed in a cleaning tank; and a control unit connected with the image acquiring unit and the weighing sensing unit, wherein the control unit is suitable for identifying the kinds of the fruits and vegetables according to the fruit and vegetable image data, and cleaning the fruits and vegetables based on the weight data of the fruits and vegetables. With the adoption of the automatic ultrasound cleaning machine and the operating method thereof, fruits and vegetables can be automatically cleaned according to the kinds and weights of the fruits and vegetables, and pesticides and contaminants on the fruits and vegetables can be effectively eliminated. With a set of water circulation system, the cleaning effect is improved on the premise of saving water. Furthermore, the automatic ultrasound cleaning machine is simple and convenient for a user to operate, and the user experience is improved.