The invention discloses antibacterial shading medical polyvinyl chloride plastic and a preparation method thereof. The antibacterial shading medical polyvinyl chloride plastic comprises, by weight, 100 parts of polyvinyl chloride, 5-90 parts of a plasticizer, 5-15 parts of an auxiliary plasticizer, 1-6 parts of a heat stabilizer, 0.1-3 parts of a ultraviolet light absorbent, 1-20 parts of a migration inhibitor, 0.1-10 parts of toner, 0.1-10 parts of titanium dioxide, 0.1-5 parts of an antibacterial material and 0.1-1 part of a lubricant. The migration inhibitor is beta-cyclodextrin. The antibacterial shading medical polyvinyl chloride plastic can effectively inhibit migration or decoloring of micromolecule substances such as a plasticizer and toner, can improve transfusion apparatus safety after disinfection, can guarantee patient usage safety, can thoroughly prevent light-avoiding agent migration and illumination-caused influence on a medical agent, does not influence drug use efficiency, has excellent dyeing resistance and anti-tarnishing performances in processing or use and does not influence PVC material transparency.